Assay Detail
Functional
CHEMBL2380102
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Cytotoxicity against human NCI-H929 cells after 72 hrs by resazurin/resorufin-based fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H929 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.91 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.19 |
| CHEMBL2377823 | — | — | 1 | 6.00 |
| CHEMBL2377825 | — | — | 1 | 5.80 |
| CHEMBL2377685 | — | — | 1 | 5.37 |
| CHEMBL2377820 | — | — | 1 | 5.17 |
| CHEMBL2103840 | DINACICLIB | 3.0 | 1 | - |
| CHEMBL2377821 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL2377823 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2377825 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2377685 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL2377820 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL2103840 | DINACICLIB | IC50 | < | 5.0 | nM | - |
| CHEMBL2377821 | — | IC50 | > | 10000.0 | nM | - |