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Assay Detail

CHEMBL2380110

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against mouse TM4 cells after 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type TM4
Confidence 1 — Organism
Curated By Autocuration

Publication

Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
Schonbrunn E, Betzi S, Alam R, Martin MP, Becker A, Han H, Francis R, Chakrasali R, Jakkaraj S, Kazi A, Sebti SM, Cubitt CL, Gebhard AW, Hazlehurst LA, Tash JS, Georg GI.
J Med Chem (2013) 56 : 3768 -3782
PubMed 23600925 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.09 5.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2377822 1 5.40
CHEMBL2377823 1 5.32
CHEMBL2377840 1 5.29
CHEMBL2377844 1 5.26
CHEMBL2377818 1 5.19
CHEMBL2377819 1 5.04
CHEMBL2377849 1 5.03
CHEMBL561114 1 4.92
CHEMBL2377864 1 4.89
CHEMBL2377839 1 4.85
CHEMBL2377825 1 4.80
CHEMBL2377685 1 -
CHEMBL2377829 1 -
CHEMBL2377833 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2377822 IC50 = 4000.0 nM 5.40
CHEMBL2377823 IC50 = 4800.0 nM 5.32
CHEMBL2377840 IC50 = 5100.0 nM 5.29
CHEMBL2377844 IC50 = 5500.0 nM 5.26
CHEMBL2377818 IC50 = 6400.0 nM 5.19
CHEMBL2377819 IC50 = 9100.0 nM 5.04
CHEMBL2377849 IC50 = 9300.0 nM 5.03
CHEMBL561114 IC50 = 12000.0 nM 4.92
CHEMBL2377864 IC50 = 13000.0 nM 4.89
CHEMBL2377839 IC50 = 14000.0 nM 4.85
CHEMBL2377825 IC50 = 16000.0 nM 4.80
CHEMBL2377685 IC50 - -
CHEMBL2377829 IC50 - -
CHEMBL2377833 IC50 > 60000.0 nM -