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Assay Detail

CHEMBL2382840

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Binding
Inhibition of aurora-B (unknown origin)
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Aurora kinase B (CHEMBL2185)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors.
Karra S, Xiao Y, Chen X, Liu-Bujalski L, Huck B, Sutton A, Goutopoulos A, Askew B, Josephson K, Jiang X, Shutes A, Shankar V, Noonan T, Garcia-Berrios G, Dong R, Dhanabal M, Tian H, Wang Z, Clark A, Goodstal S.
Bioorg Med Chem Lett (2013) 23 : 3081 -3087
PubMed 23570792 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 8.51 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2380834 1 9.40
CHEMBL2380829 1 9.30
CHEMBL2380831 1 9.22
CHEMBL2380833 1 9.15
CHEMBL2380832 1 9.10
CHEMBL2380838 1 9.00
CHEMBL2380845 1 9.00
CHEMBL2380824 1 9.00
CHEMBL2380825 1 9.00
CHEMBL2380827 1 9.00
CHEMBL2380830 1 9.00
CHEMBL2380835 1 9.00
CHEMBL2380823 1 8.70
CHEMBL2380839 1 8.70
CHEMBL2380826 1 8.70
CHEMBL2380828 1 8.22
CHEMBL2380846 1 7.89
CHEMBL2380848 1 7.68
CHEMBL2380847 1 7.10
CHEMBL2380843 1 6.76
CHEMBL2380840 1 5.84
CHEMBL110381 1 -
CHEMBL2380841 1 -
CHEMBL2380842 1 -
CHEMBL2380844 1 -
CHEMBL2380836 1 -
CHEMBL2380837 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2380834 IC50 = 0.4 nM 9.40
CHEMBL2380829 IC50 = 0.5 nM 9.30
CHEMBL2380831 IC50 = 0.6 nM 9.22
CHEMBL2380833 IC50 = 0.7 nM 9.15
CHEMBL2380832 IC50 = 0.8 nM 9.10
CHEMBL2380838 IC50 = 1.0 nM 9.00
CHEMBL2380845 IC50 = 1.0 nM 9.00
CHEMBL2380824 IC50 = 1.0 nM 9.00
CHEMBL2380825 IC50 = 1.0 nM 9.00
CHEMBL2380827 IC50 = 1.0 nM 9.00
CHEMBL2380830 IC50 = 1.0 nM 9.00
CHEMBL2380835 IC50 = 1.0 nM 9.00
CHEMBL2380823 IC50 = 2.0 nM 8.70
CHEMBL2380839 IC50 = 2.0 nM 8.70
CHEMBL2380826 IC50 = 2.0 nM 8.70
CHEMBL2380828 IC50 = 6.0 nM 8.22
CHEMBL2380846 IC50 = 13.0 nM 7.89
CHEMBL2380848 IC50 = 21.0 nM 7.68
CHEMBL2380847 IC50 = 79.0 nM 7.10
CHEMBL2380843 IC50 = 174.0 nM 6.76
CHEMBL2380840 IC50 = 1440.0 nM 5.84
CHEMBL110381 IC50 - -
CHEMBL2380841 IC50 - -
CHEMBL2380842 IC50 - -
CHEMBL2380844 IC50 - -
CHEMBL2380836 IC50 - -
CHEMBL2380837 IC50 - -