Assay Detail
Binding
CHEMBL2382890
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Binding affinity to Keap1 kelch domain (unknown origin) by competitive SPR assay
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Kelch-like ECH-associated protein 1 (CHEMBL2069156) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 4 | - | - |
| Kd | 4 | 5.24 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2381968 | — | — | 1 | 6.00 |
| CHEMBL1460757 | — | — | 1 | 5.72 |
| CHEMBL2381969 | — | — | 1 | 4.00 |
| CHEMBL2381965 | — | — | 1 | - |
| CHEMBL2381967 | — | — | 1 | - |
| CHEMBL2381964 | — | — | 1 | - |
| CHEMBL2381966 | — | — | 1 | - |
| CHEMBL2381970 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2381968 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL1460757 | — | Kd | = | 1900.0 | nM | 5.72 |
| CHEMBL2381969 | — | Kd | = | 100000.0 | nM | 4.00 |
| CHEMBL2381965 | — | Activity | - | — | - | |
| CHEMBL2381967 | — | Activity | - | — | - | |
| CHEMBL2381964 | — | Activity | - | — | - | |
| CHEMBL2381966 | — | Activity | - | — | - | |
| CHEMBL2381970 | — | Kd | = | 700000.0 | nM | - |