Assay Detail
Binding
CHEMBL2382937
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant caspase-3 assessed as Ac-DEVD-AMC conversion to 7-amino-4-methylcoumarin incubated for 10 mins prior to substrate addition measured after 10 mins by spectrophotometric analysis
9
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, 18F-radiolabeling, and in vivo biodistribution studies of N-fluorohydroxybutyl isatin sulfonamides using positron emission tomography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.31 | 7.93 |
| Ki | 2 | 7.52 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2381343 | — | — | 1 | 7.93 |
| CHEMBL293034 | — | — | 1 | 7.82 |
| CHEMBL2381345 | — | — | 1 | 7.63 |
| CHEMBL2381348 | — | — | 1 | 7.59 |
| CHEMBL2381346 | — | — | 1 | 7.25 |
| CHEMBL60190 | — | — | 2 | 7.22 |
| CHEMBL2381344 | — | — | 1 | 6.97 |
| CHEMBL2381349 | — | — | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2381343 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL293034 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL2381345 | — | IC50 | = | 23.3 | nM | 7.63 |
| CHEMBL2381348 | — | IC50 | = | 25.9 | nM | 7.59 |
| CHEMBL2381346 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL60190 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL60190 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL2381344 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL2381349 | — | IC50 | = | 187.0 | nM | 6.73 |