Assay Detail
Functional
CHEMBL2383352
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at CB1 receptor in mouse Neuro2a cells assessed as inhibition of forskolin-stimulated adenylyl cyclase activity after 15 mins by liquid scintillation spectrophotometry
8
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Neuro2a |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of aminoalkylindole derivatives as cannabinoid receptor ligands with potential for treatment of alcohol abuse.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.66 | 8.77 |
| IC50 | 2 | 7.00 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2380420 | — | — | 2 | 8.77 |
| CHEMBL2380416 | — | — | 1 | 7.89 |
| CHEMBL2380428 | — | — | 1 | 7.81 |
| CHEMBL2380417 | — | — | 2 | 7.62 |
| CHEMBL2380408 | — | — | 1 | 7.43 |
| CHEMBL2380418 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2380420 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL2380416 | — | Ki | = | 12.9 | nM | 7.89 |
| CHEMBL2380428 | — | Ki | = | 15.4 | nM | 7.81 |
| CHEMBL2380417 | — | Ki | = | 24.2 | nM | 7.62 |
| CHEMBL2380408 | — | Ki | = | 37.3 | nM | 7.43 |
| CHEMBL2380420 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2380417 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL2380418 | — | Ki | = | 387.0 | nM | 6.41 |