Assay Detail
Binding
CHEMBL2383450
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Agonist activity at human mGlu2 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by HTRF assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | AV12 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological characterization of 4-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: identification of new potent and selective metabotropic glutamate 2/3 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 7.88 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2381640 | — | — | 1 | 9.80 |
| CHEMBL2381652 | — | — | 1 | 9.25 |
| CHEMBL2381641 | — | — | 1 | 8.89 |
| CHEMBL2381642 | — | — | 1 | 8.12 |
| CHEMBL2381643 | — | — | 1 | 8.12 |
| CHEMBL2381644 | — | — | 1 | 8.09 |
| CHEMBL2381645 | — | — | 1 | 7.91 |
| CHEMBL2381647 | — | — | 1 | 7.67 |
| CHEMBL365368 | — | — | 1 | 7.54 |
| CHEMBL2381646 | — | — | 1 | 7.32 |
| CHEMBL192051 | — | — | 1 | 7.20 |
| CHEMBL2381649 | — | — | 1 | 6.59 |
| CHEMBL2381651 | — | — | 1 | 5.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2381640 | — | EC50 | = | 0.16 | nM | 9.80 |
| CHEMBL2381652 | — | EC50 | = | 0.56 | nM | 9.25 |
| CHEMBL2381641 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL2381642 | — | EC50 | = | 7.6 | nM | 8.12 |
| CHEMBL2381643 | — | EC50 | = | 7.5 | nM | 8.12 |
| CHEMBL2381644 | — | EC50 | = | 8.2 | nM | 8.09 |
| CHEMBL2381645 | — | EC50 | = | 12.2 | nM | 7.91 |
| CHEMBL2381647 | — | EC50 | = | 21.2 | nM | 7.67 |
| CHEMBL365368 | — | EC50 | = | 28.6 | nM | 7.54 |
| CHEMBL2381646 | — | EC50 | = | 47.9 | nM | 7.32 |
| CHEMBL192051 | — | EC50 | = | 63.6 | nM | 7.20 |
| CHEMBL2381649 | — | EC50 | = | 257.0 | nM | 6.59 |
| CHEMBL2381651 | — | EC50 | = | 1170.0 | nM | 5.93 |