Compound Detail
CHEMBL2381646
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Basic Information
| ChEMBL ID | CHEMBL2381646 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BIHSLTSGYFDSHV-RTHBWCHNSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
200.2
MW (Da)
-1.55
ALogP
4
HBA
4
HBD
126.6
PSA (Ų)
0.43
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 7.32
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 CHEMBL5137 | EC50 | 7.32 | 7.32 | 47.9 | 1 |
| Metabotropic glutamate receptor 3 CHEMBL2888 | EC50 | 7.24 | 7.24 | 57.1 | 1 |
| Metabotropic glutamate receptor 6 CHEMBL4573 | EC50 | 4.93 | 4.93 | 11800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 | EC50 | = | 47.9 | nM | 7.32 | Agonist activity at human mGlu2 receptor expressed in golden Syrian hamster AV12... | 23675965 |
| Metabotropic glutamate receptor 3 | EC50 | = | 57.1 | nM | 7.24 | Agonist activity at human mGlu3 receptor expressed in golden Syrian hamster AV12... | 23675965 |
| Metabotropic glutamate receptor 6 | EC50 | = | 11800.0 | nM | 4.93 | Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12... | 23675965 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23675965 | 10.1021/jm4000165 | Metabotropic glutamate receptor 6 | 2 |
| 23675965 | 10.1021/jm4000165 | Metabotropic glutamate receptor 3 | 2 |
| 23675965 | 10.1021/jm4000165 | Metabotropic glutamate receptor 2 | 2 |
| 23675965 | 10.1021/jm4000165 | Metabotropic glutamate receptor 8 | 1 |
Data from ChEMBL 36 via Core Engine