Assay Detail
Binding
CHEMBL2383516
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Antagonist activity at human GST-tagged MDM2 assessed as inhibition of binding to full length p53
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of the p53/hdm2 protein-protein interaction-path to the clinic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.33 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405395 | — | — | 1 | 8.30 |
| CHEMBL191334 | NUTLIN-3 | — | 1 | 7.00 |
| CHEMBL2381406 | — | — | 1 | 7.00 |
| CHEMBL1818538 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405395 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2381406 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1818538 | — | IC50 | = | 100.0 | nM | 7.00 |