Assay Detail
Functional
CHEMBL2383589
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Antiviral activity against HIV1 SF162 infected in HEK293T cells by luciferase reporter gene assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | HEK-293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Addition of artificial salt bridge by Ile646Lys mutation in gp41 coiled-coil domain regulates 6-helical bundle formation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.52 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2380932 | — | — | 1 | 7.44 |
| CHEMBL2380933 | — | — | 1 | 6.28 |
| CHEMBL3037905 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2380932 | — | IC50 | = | 35.97 | nM | 7.44 |
| CHEMBL2380933 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL3037905 | — | IC50 | = | 1430.0 | nM | 5.84 |