Assay Detail
Functional
CHEMBL2383763
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Negative chronotropic activity in guinea pig right atrium assessed as decrease in atrial rate
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Cardiac atrium |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Ligand based approach to L-type calcium channel by imidazo[2,1-b]thiazole-1,4-dihydropyridines: from heart activity to brain affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 5.35 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 7.41 |
| CHEMBL2381470 | — | — | 1 | 5.97 |
| CHEMBL2381468 | — | — | 1 | 5.89 |
| CHEMBL2381472 | — | — | 1 | 5.67 |
| CHEMBL2381471 | — | — | 1 | 5.64 |
| CHEMBL2381582 | — | — | 1 | 5.58 |
| CHEMBL2381467 | — | — | 1 | 5.13 |
| CHEMBL2381465 | — | — | 1 | 4.90 |
| CHEMBL2381462 | — | — | 1 | 4.61 |
| CHEMBL2381464 | — | — | 1 | 4.55 |
| CHEMBL2381463 | — | — | 1 | 4.40 |
| CHEMBL2381469 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL2381470 | — | EC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL2381468 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2381472 | — | EC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL2381471 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL2381582 | — | EC50 | = | 2630.0 | nM | 5.58 |
| CHEMBL2381467 | — | EC50 | = | 7490.0 | nM | 5.13 |
| CHEMBL2381465 | — | EC50 | = | 12460.0 | nM | 4.90 |
| CHEMBL2381462 | — | EC50 | = | 24390.0 | nM | 4.61 |
| CHEMBL2381464 | — | EC50 | = | 28440.0 | nM | 4.55 |
| CHEMBL2381463 | — | EC50 | = | 39910.0 | nM | 4.40 |
| CHEMBL2381469 | — | EC50 | = | 40500.0 | nM | 4.39 |