Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2383873

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of MetAP2 (unknown origin) after 4 hrs
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Methionine aminopeptidase 2 (CHEMBL3922)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and antitumor activity of 1,3,4-oxadiazole possessing 1,4-benzodioxan moiety as a novel class of potent methionine aminopeptidase type II inhibitors.
Sun J, Li MH, Qian SS, Guo FJ, Dang XF, Wang XM, Xue YR, Zhu HL.
Bioorg Med Chem Lett (2013) 23 : 2876 -2879
PubMed 23582273 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.12 5.88

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL424278 O-CHLOROACETYLCARBAMOYLFUMAGILLOL 2.0 1 5.88
CHEMBL2381120 1 5.68
CHEMBL2381121 1 5.32
CHEMBL2381122 1 5.20
CHEMBL2381124 1 5.10
CHEMBL2381125 1 5.08
CHEMBL2381123 1 5.00
CHEMBL2381126 1 4.97
CHEMBL2380996 1 4.90
CHEMBL2381002 1 4.86
CHEMBL2381001 1 4.74
CHEMBL2381000 1 4.66

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL424278 O-CHLOROACETYLCARBAMOYLFUMAGILLOL IC50 = 1320.0 nM 5.88
CHEMBL2381120 IC50 = 2080.0 nM 5.68
CHEMBL2381121 IC50 = 4790.0 nM 5.32
CHEMBL2381122 IC50 = 6330.0 nM 5.20
CHEMBL2381124 IC50 = 7920.0 nM 5.10
CHEMBL2381125 IC50 = 8410.0 nM 5.08
CHEMBL2381123 IC50 = 10040.0 nM 5.00
CHEMBL2381126 IC50 = 10710.0 nM 4.97
CHEMBL2380996 IC50 = 12660.0 nM 4.90
CHEMBL2381002 IC50 = 13950.0 nM 4.86
CHEMBL2381001 IC50 = 18240.0 nM 4.74
CHEMBL2381000 IC50 = 22030.0 nM 4.66