Assay Detail
ADMET
CHEMBL2383979
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Cytotoxicity against human 16HBE14o- cells harboring wild type EGFR assessed as growth inhibition after 72 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | 16HBE14o- |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel hybrids of (phenylsulfonyl)furoxan and anilinopyrimidine as potent and selective epidermal growth factor receptor inhibitors for intervention of non-small-cell lung cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.57 | 6.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2381513 | — | — | 1 | 6.15 |
| CHEMBL1229592 | — | — | 1 | 5.87 |
| CHEMBL2381516 | — | — | 1 | 5.83 |
| CHEMBL2381514 | — | — | 1 | 5.81 |
| CHEMBL2381504 | — | — | 1 | 5.75 |
| CHEMBL2381505 | — | — | 1 | 5.73 |
| CHEMBL2381506 | — | — | 1 | 5.69 |
| CHEMBL2381515 | — | — | 1 | 5.64 |
| CHEMBL2381507 | — | — | 1 | 5.59 |
| CHEMBL2381509 | — | — | 1 | 5.58 |
| CHEMBL2381510 | — | — | 1 | 5.50 |
| CHEMBL2381512 | — | — | 1 | 5.47 |
| CHEMBL2381508 | — | — | 1 | 5.38 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 4.90 |
| CHEMBL2381511 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2381513 | — | IC50 | = | 707.0 | nM | 6.15 |
| CHEMBL1229592 | — | IC50 | = | 1355.0 | nM | 5.87 |
| CHEMBL2381516 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL2381514 | — | IC50 | = | 1551.0 | nM | 5.81 |
| CHEMBL2381504 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2381505 | — | IC50 | = | 1851.0 | nM | 5.73 |
| CHEMBL2381506 | — | IC50 | = | 2043.0 | nM | 5.69 |
| CHEMBL2381515 | — | IC50 | = | 2275.0 | nM | 5.64 |
| CHEMBL2381507 | — | IC50 | = | 2584.0 | nM | 5.59 |
| CHEMBL2381509 | — | IC50 | = | 2615.0 | nM | 5.58 |
| CHEMBL2381510 | — | IC50 | = | 3155.0 | nM | 5.50 |
| CHEMBL2381512 | — | IC50 | = | 3401.0 | nM | 5.47 |
| CHEMBL2381508 | — | IC50 | = | 4153.0 | nM | 5.38 |
| CHEMBL939 | GEFITINIB | IC50 | = | 12710.0 | nM | 4.90 |
| CHEMBL2381511 | — | IC50 | = | 23860.0 | nM | 4.62 |