Assay Detail
Functional
CHEMBL2383983
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against gefitinib-resistant human NCI-H1975 cells harboring EGFR L858R/T90M double mutant assessed as growth inhibition after 72 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1975 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel hybrids of (phenylsulfonyl)furoxan and anilinopyrimidine as potent and selective epidermal growth factor receptor inhibitors for intervention of non-small-cell lung cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.43 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2381511 | — | — | 1 | 7.54 |
| CHEMBL2381509 | — | — | 1 | 7.37 |
| CHEMBL1229592 | — | — | 1 | 7.34 |
| CHEMBL2381506 | — | — | 1 | 7.20 |
| CHEMBL2381508 | — | — | 1 | 7.16 |
| CHEMBL2381505 | — | — | 1 | 6.61 |
| CHEMBL2381516 | — | — | 1 | 6.51 |
| CHEMBL2381507 | — | — | 1 | 6.40 |
| CHEMBL2381510 | — | — | 1 | 6.33 |
| CHEMBL2381504 | — | — | 1 | 6.07 |
| CHEMBL2381515 | — | — | 1 | 5.99 |
| CHEMBL2381513 | — | — | 1 | 5.82 |
| CHEMBL2381514 | — | — | 1 | 5.70 |
| CHEMBL2381512 | — | — | 1 | 5.23 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2381511 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2381509 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1229592 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL2381506 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL2381508 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL2381505 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL2381516 | — | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL2381507 | — | IC50 | = | 396.0 | nM | 6.40 |
| CHEMBL2381510 | — | IC50 | = | 471.0 | nM | 6.33 |
| CHEMBL2381504 | — | IC50 | = | 855.0 | nM | 6.07 |
| CHEMBL2381515 | — | IC50 | = | 1027.0 | nM | 5.99 |
| CHEMBL2381513 | — | IC50 | = | 1514.0 | nM | 5.82 |
| CHEMBL2381514 | — | IC50 | = | 2017.0 | nM | 5.70 |
| CHEMBL2381512 | — | IC50 | = | 5931.0 | nM | 5.23 |
| CHEMBL939 | GEFITINIB | IC50 | = | 6917.0 | nM | 5.16 |