Assay Detail
Binding
CHEMBL2383984
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type EGFR (unknown origin) after 1.5 hrs by FRET-based Z'Lyte assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel hybrids of (phenylsulfonyl)furoxan and anilinopyrimidine as potent and selective epidermal growth factor receptor inhibitors for intervention of non-small-cell lung cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.44 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 10.00 |
| CHEMBL1229592 | — | — | 1 | 8.49 |
| CHEMBL2381516 | — | — | 1 | 7.41 |
| CHEMBL2381504 | — | — | 1 | 7.38 |
| CHEMBL2381514 | — | — | 1 | 7.29 |
| CHEMBL2381509 | — | — | 1 | 7.28 |
| CHEMBL2381506 | — | — | 1 | 7.23 |
| CHEMBL2381515 | — | — | 1 | 7.23 |
| CHEMBL2381505 | — | — | 1 | 7.14 |
| CHEMBL2381510 | — | — | 1 | 7.00 |
| CHEMBL2381507 | — | — | 1 | 7.00 |
| CHEMBL2381508 | — | — | 1 | 6.76 |
| CHEMBL2381511 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL939 | GEFITINIB | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL1229592 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL2381516 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL2381504 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL2381514 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL2381509 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL2381506 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL2381515 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL2381505 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL2381510 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL2381507 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL2381508 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL2381511 | — | IC50 | = | 292.0 | nM | 6.54 |