Assay Detail
Functional
CHEMBL2383985
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against gefitinib-sensitive human HCC827 cells harboring EGFR E746_A740 deletion mutant assessed as growth inhibition after 72 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCC827 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel hybrids of (phenylsulfonyl)furoxan and anilinopyrimidine as potent and selective epidermal growth factor receptor inhibitors for intervention of non-small-cell lung cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.56 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2381508 | — | — | 1 | 8.22 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 8.22 |
| CHEMBL2381511 | — | — | 1 | 8.15 |
| CHEMBL2381506 | — | — | 1 | 8.15 |
| CHEMBL1229592 | — | — | 1 | 8.10 |
| CHEMBL2381514 | — | — | 1 | 8.05 |
| CHEMBL2381509 | — | — | 1 | 8.00 |
| CHEMBL2381515 | — | — | 1 | 7.68 |
| CHEMBL2381507 | — | — | 1 | 7.66 |
| CHEMBL2381504 | — | — | 1 | 7.48 |
| CHEMBL2381505 | — | — | 1 | 7.42 |
| CHEMBL2381510 | — | — | 1 | 7.39 |
| CHEMBL2381513 | — | — | 1 | 7.00 |
| CHEMBL2381516 | — | — | 1 | 6.54 |
| CHEMBL2381512 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2381508 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL939 | GEFITINIB | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2381511 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2381506 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1229592 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2381514 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2381509 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2381515 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2381507 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2381504 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2381505 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL2381510 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2381513 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2381516 | — | IC50 | = | 291.0 | nM | 6.54 |
| CHEMBL2381512 | — | IC50 | = | 4294.0 | nM | 5.37 |