Assay Detail
Binding
CHEMBL2384040
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Inhibition of human cathepsin-S
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of proline analogues as potent and selective cathepsin S inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 8.23 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2380725 | — | — | 1 | 8.96 |
| CHEMBL222649 | — | — | 1 | 8.72 |
| CHEMBL2380724 | — | — | 1 | 8.70 |
| CHEMBL2380727 | — | — | 1 | 8.64 |
| CHEMBL2380718 | — | — | 1 | 8.62 |
| CHEMBL2380720 | — | — | 1 | 8.57 |
| CHEMBL2380716 | — | — | 1 | 8.52 |
| CHEMBL2380717 | — | — | 1 | 8.51 |
| CHEMBL2380729 | — | — | 1 | 8.49 |
| CHEMBL2380728 | — | — | 1 | 8.49 |
| CHEMBL2380735 | — | — | 1 | 8.48 |
| CHEMBL2380723 | — | — | 1 | 8.48 |
| CHEMBL2380721 | — | — | 1 | 8.48 |
| CHEMBL2380719 | — | — | 1 | 8.48 |
| CHEMBL2380618 | — | — | 1 | 8.48 |
| CHEMBL2380616 | — | — | 1 | 8.46 |
| CHEMBL2380619 | — | — | 1 | 8.46 |
| CHEMBL2380722 | — | — | 1 | 8.43 |
| CHEMBL2380726 | — | — | 1 | 8.39 |
| CHEMBL2380736 | — | — | 1 | 8.37 |
| CHEMBL2380621 | — | — | 1 | 7.91 |
| CHEMBL2380731 | — | — | 1 | 7.74 |
| CHEMBL2380622 | — | — | 1 | 7.68 |
| CHEMBL2380732 | — | — | 1 | 7.61 |
| CHEMBL2380734 | — | — | 1 | 7.44 |
| CHEMBL2380620 | — | — | 1 | 7.34 |
| CHEMBL2380714 | — | — | 1 | 7.08 |
| CHEMBL2380617 | — | — | 1 | 6.81 |
| CHEMBL2380715 | — | — | 1 | - |
| CHEMBL2380733 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2380725 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL222649 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL2380724 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2380727 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL2380718 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL2380720 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL2380716 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2380717 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL2380729 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL2380728 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL2380735 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL2380723 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL2380721 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL2380719 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL2380618 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL2380616 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL2380619 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL2380722 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL2380726 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL2380736 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL2380621 | — | IC50 | = | 12.4 | nM | 7.91 |
| CHEMBL2380731 | — | IC50 | = | 18.1 | nM | 7.74 |
| CHEMBL2380622 | — | IC50 | = | 20.7 | nM | 7.68 |
| CHEMBL2380732 | — | IC50 | = | 24.6 | nM | 7.61 |
| CHEMBL2380734 | — | IC50 | = | 36.6 | nM | 7.44 |
| CHEMBL2380620 | — | IC50 | = | 45.4 | nM | 7.34 |
| CHEMBL2380714 | — | IC50 | = | 83.7 | nM | 7.08 |
| CHEMBL2380617 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL2380715 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2380733 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL2380730 | — | IC50 | > | 100.0 | nM | - |