Assay Detail
Binding
CHEMBL2384178
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Inhibition of human recombinant carboxy-terminal his-tagged LDHB (1 to 333) expressed in insect cells using pyruvate as substrate after 10 mins by UV endpoint analysis
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.86 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2382403 | — | — | 1 | 5.64 |
| CHEMBL2382404 | — | — | 1 | 5.62 |
| CHEMBL2382401 | — | — | 1 | 5.52 |
| CHEMBL2382402 | — | — | 1 | 5.43 |
| CHEMBL2382405 | — | — | 1 | 5.11 |
| CHEMBL2382337 | — | — | 1 | 4.96 |
| CHEMBL15976 | OXAMATE | — | 1 | 4.47 |
| CHEMBL2382400 | — | — | 1 | 4.37 |
| CHEMBL210497 | — | — | 1 | 4.25 |
| CHEMBL2382397 | — | — | 1 | 4.03 |
| CHEMBL2382389 | — | — | 1 | 4.01 |
| CHEMBL2382338 | — | — | 1 | - |
| CHEMBL2382339 | — | — | 1 | - |
| CHEMBL2382390 | — | — | 1 | - |
| CHEMBL2382391 | — | — | 1 | - |
| CHEMBL2382392 | — | — | 1 | - |
| CHEMBL2382393 | — | — | 1 | - |
| CHEMBL2382394 | — | — | 1 | - |
| CHEMBL2382395 | — | — | 1 | - |
| CHEMBL2382396 | — | — | 1 | - |
| CHEMBL2382398 | — | — | 1 | - |
| CHEMBL2382399 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2382403 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL2382404 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL2382401 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2382402 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL2382405 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL2382337 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL15976 | OXAMATE | IC50 | = | 33800.0 | nM | 4.47 |
| CHEMBL2382400 | — | IC50 | = | 42800.0 | nM | 4.37 |
| CHEMBL210497 | — | IC50 | = | 56400.0 | nM | 4.25 |
| CHEMBL2382397 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL2382389 | — | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL2382338 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2382339 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2382390 | — | IC50 | - | — | - | |
| CHEMBL2382391 | — | IC50 | - | — | - | |
| CHEMBL2382392 | — | IC50 | - | — | - | |
| CHEMBL2382393 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2382394 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2382395 | — | IC50 | - | — | - | |
| CHEMBL2382396 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2382398 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2382399 | — | IC50 | > | 100000.0 | nM | - |