Assay Detail
Functional
CHEMBL2384300
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 expressing VSV glycoprotein plasmid infected in human 293T cells treated 15 mins before viral infection measured after 48 hrs by luciferase reporter gene assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | 293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, and biological evaluation of new 2'-deoxy-2'-fluoro-4'-triazole cytidine nucleosides as potent antiviral agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.68 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL519846 | RO-0622 | 3.0 | 1 | 9.52 |
| CHEMBL2380561 | — | — | 1 | 7.10 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.08 |
| CHEMBL2380664 | — | — | 1 | 7.08 |
| CHEMBL2380663 | — | — | 1 | 7.05 |
| CHEMBL2380562 | — | — | 1 | 6.52 |
| CHEMBL2380662 | — | — | 1 | 6.22 |
| CHEMBL2380666 | — | — | 1 | 6.22 |
| CHEMBL2380661 | — | — | 1 | 5.89 |
| CHEMBL2380665 | — | — | 1 | 5.43 |
| CHEMBL2380563 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL519846 | RO-0622 | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2380561 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL2380664 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL2380663 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2380562 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2380662 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2380666 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2380661 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2380665 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL2380563 | — | EC50 | = | 4800.0 | nM | 5.32 |