Assay Detail
Binding
CHEMBL2384302
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 15 mins prior to substrate addition measured after 30 mins by Ellman's method
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A facile chemo-, regio- and stereoselective synthesis and cholinesterase inhibitory activity of spirooxindole-pyrrolizine-piperidine hybrids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.98 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 5.68 |
| CHEMBL2380674 | — | — | 1 | 5.48 |
| CHEMBL2380676 | — | — | 1 | 5.47 |
| CHEMBL2380673 | — | — | 1 | 5.37 |
| CHEMBL2380671 | — | — | 1 | 5.29 |
| CHEMBL2380667 | — | — | 1 | 5.24 |
| CHEMBL2380675 | — | — | 1 | 5.12 |
| CHEMBL2332539 | — | — | 1 | 5.06 |
| CHEMBL2332537 | — | — | 1 | 5.01 |
| CHEMBL2380669 | — | — | 1 | 4.95 |
| CHEMBL2332536 | — | — | 1 | 4.93 |
| CHEMBL2332547 | — | — | 1 | 4.86 |
| CHEMBL2380670 | — | — | 1 | 4.84 |
| CHEMBL350032 | — | — | 1 | 4.82 |
| CHEMBL2380668 | — | — | 1 | 4.80 |
| CHEMBL2332546 | — | — | 1 | 4.80 |
| CHEMBL2332535 | — | — | 1 | 4.79 |
| CHEMBL2332538 | — | — | 1 | 4.76 |
| CHEMBL156016 | — | — | 1 | 4.75 |
| CHEMBL454594 | — | — | 1 | 4.74 |
| CHEMBL152675 | — | — | 1 | 4.66 |
| CHEMBL2380677 | — | — | 1 | 4.65 |
| CHEMBL2380672 | — | — | 1 | 4.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL659 | GALANTAMINE | IC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL2380674 | — | IC50 | = | 3330.0 | nM | 5.48 |
| CHEMBL2380676 | — | IC50 | = | 3360.0 | nM | 5.47 |
| CHEMBL2380673 | — | IC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL2380671 | — | IC50 | = | 5080.0 | nM | 5.29 |
| CHEMBL2380667 | — | IC50 | = | 5810.0 | nM | 5.24 |
| CHEMBL2380675 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL2332539 | — | IC50 | = | 8720.0 | nM | 5.06 |
| CHEMBL2332537 | — | IC50 | = | 9760.0 | nM | 5.01 |
| CHEMBL2380669 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL2332536 | — | IC50 | = | 11810.0 | nM | 4.93 |
| CHEMBL2332547 | — | IC50 | = | 13840.0 | nM | 4.86 |
| CHEMBL2380670 | — | IC50 | = | 14520.0 | nM | 4.84 |
| CHEMBL350032 | — | IC50 | = | 15120.0 | nM | 4.82 |
| CHEMBL2380668 | — | IC50 | = | 15720.0 | nM | 4.80 |
| CHEMBL2332546 | — | IC50 | = | 15750.0 | nM | 4.80 |
| CHEMBL2332535 | — | IC50 | = | 16320.0 | nM | 4.79 |
| CHEMBL2332538 | — | IC50 | = | 17390.0 | nM | 4.76 |
| CHEMBL156016 | — | IC50 | = | 17680.0 | nM | 4.75 |
| CHEMBL454594 | — | IC50 | = | 18060.0 | nM | 4.74 |
| CHEMBL152675 | — | IC50 | = | 22040.0 | nM | 4.66 |
| CHEMBL2380677 | — | IC50 | = | 22320.0 | nM | 4.65 |
| CHEMBL2380672 | — | IC50 | = | 29510.0 | nM | 4.53 |