Assay Detail
Binding
CHEMBL2384495
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Inhibition of mouse EL expressed in HEK293 cells using PED-A1 as substrate by spectrophotometry
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A thiocarbamate inhibitor of endothelial lipase raises HDL cholesterol levels in mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.25 | 6.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2381067 | — | — | 1 | 6.33 |
| CHEMBL2381069 | — | — | 1 | 6.17 |
| CHEMBL2381068 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2381067 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL2381069 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL2381068 | — | IC50 | > | 33000.0 | nM | - |