Assay Detail
Binding
CHEMBL2384629
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cathepsin L (unknown origin) using Z-FR-AMC as substrate after 30 mins by fluorescence assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chalcones, inhibitors for topoisomerase I and cathepsin B and L, as potential anti-cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.70 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2368566 | — | — | 1 | 7.08 |
| CHEMBL2382116 | — | — | 1 | 5.50 |
| CHEMBL2382117 | — | — | 1 | 5.33 |
| CHEMBL2382119 | — | — | 1 | 5.03 |
| CHEMBL2382054 | — | — | 1 | 4.53 |
| CHEMBL141530 | ECHINATIN | — | 1 | 4.52 |
| CHEMBL2382114 | — | — | 1 | 4.48 |
| CHEMBL2382113 | — | — | 1 | 4.41 |
| CHEMBL2382056 | — | — | 1 | 4.34 |
| CHEMBL2382118 | — | — | 1 | 4.25 |
| CHEMBL2382055 | — | — | 1 | 4.17 |
| CHEMBL2382112 | — | — | 1 | 4.13 |
| CHEMBL2382115 | — | — | 1 | 4.04 |
| CHEMBL2148111 | — | — | 1 | 4.01 |
| CHEMBL8102 | — | — | 1 | - |
| CHEMBL1928752 | — | — | 1 | - |
| CHEMBL2382059 | — | — | 1 | - |
| CHEMBL2382058 | — | — | 1 | - |
| CHEMBL2382057 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2368566 | — | IC50 | = | 83.7 | nM | 7.08 |
| CHEMBL2382116 | — | IC50 | = | 3150.0 | nM | 5.50 |
| CHEMBL2382117 | — | IC50 | = | 4720.0 | nM | 5.33 |
| CHEMBL2382119 | — | IC50 | = | 9420.0 | nM | 5.03 |
| CHEMBL2382054 | — | IC50 | = | 29810.0 | nM | 4.53 |
| CHEMBL141530 | ECHINATIN | IC50 | = | 30340.0 | nM | 4.52 |
| CHEMBL2382114 | — | IC50 | = | 32850.0 | nM | 4.48 |
| CHEMBL2382113 | — | IC50 | = | 39310.0 | nM | 4.41 |
| CHEMBL2382056 | — | IC50 | = | 45270.0 | nM | 4.34 |
| CHEMBL2382118 | — | IC50 | = | 56510.0 | nM | 4.25 |
| CHEMBL2382055 | — | IC50 | = | 67510.0 | nM | 4.17 |
| CHEMBL2382112 | — | IC50 | = | 73220.0 | nM | 4.13 |
| CHEMBL2382115 | — | IC50 | = | 91170.0 | nM | 4.04 |
| CHEMBL2148111 | — | IC50 | = | 98680.0 | nM | 4.01 |
| CHEMBL8102 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1928752 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2382059 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2382058 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2382057 | — | IC50 | > | 100000.0 | nM | - |