Assay Detail
Binding
CHEMBL2387873
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of fluorescent ES2 from human recombinant ERalpha after 2 hrs by fluorimetric analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of mixed (E,Z)-, (E)-, and (Z)-norendoxifen with dual aromatase inhibitory and estrogen receptor modulatory activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.52 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2386284 | — | — | 1 | 7.77 |
| CHEMBL3350384 | — | — | 1 | 7.57 |
| CHEMBL2386285 | — | — | 1 | 7.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2386284 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3350384 | — | EC50 | = | 26.9 | nM | 7.57 |
| CHEMBL2386285 | — | EC50 | = | 58.7 | nM | 7.23 |