Assay Detail
Binding
CHEMBL2387946
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Inhibition of mu opioid receptor in guinea pig ileum assessed as inhibition of electrically-stimulated muscle contraction
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Effect of anchoring 4-anilidopiperidines to opioid peptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.86 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL596 | FENTANYL | 4.0 | 1 | 8.47 |
| CHEMBL385909 | — | — | 1 | 5.89 |
| CHEMBL214285 | — | — | 1 | 5.85 |
| CHEMBL214657 | — | — | 1 | 5.52 |
| CHEMBL2387336 | — | — | 1 | 5.41 |
| CHEMBL386990 | — | — | 1 | 5.28 |
| CHEMBL216492 | — | — | 1 | 5.25 |
| CHEMBL2387335 | — | — | 1 | 5.23 |
| CHEMBL2387333 | — | — | 1 | - |
| CHEMBL2387332 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL596 | FENTANYL | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL385909 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL214285 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL214657 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2387336 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL386990 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL216492 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL2387335 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL2387333 | — | IC50 | - | — | - | |
| CHEMBL2387332 | — | IC50 | - | — | - |