Assay Detail
Functional
CHEMBL2387965
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Cytotoxicity against human MM1S cells after 72 hrs by CellTitre Glo assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MM1.S |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.74 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2387465 | — | — | 1 | 6.37 |
| CHEMBL2387464 | — | — | 1 | 5.72 |
| CHEMBL2387471 | — | — | 1 | 5.13 |
| CHEMBL2387463 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2387465 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL2387464 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2387471 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL2387463 | — | IC50 | > | 20000.0 | nM | - |