Assay Detail
Binding
CHEMBL2387969
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PIM2 (unknown origin) using FAM-pimtide as substrate after 90 mins by spectrophotometry in presence of ATP
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-2 (CHEMBL4523) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 8.79 | 10.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2387464 | — | — | 1 | 10.49 |
| CHEMBL2387465 | — | — | 1 | 10.43 |
| CHEMBL2387471 | — | — | 1 | 10.12 |
| CHEMBL2387463 | — | — | 1 | 10.03 |
| CHEMBL2387474 | — | — | 1 | 9.77 |
| CHEMBL2387473 | — | — | 1 | 9.28 |
| CHEMBL2387475 | — | — | 1 | 9.19 |
| CHEMBL2387472 | — | — | 1 | 8.89 |
| CHEMBL2387479 | — | — | 1 | 8.70 |
| CHEMBL2387469 | — | — | 1 | 8.66 |
| CHEMBL2387468 | — | — | 1 | 8.55 |
| CHEMBL2387462 | — | — | 1 | 8.31 |
| CHEMBL2387478 | — | — | 1 | 8.23 |
| CHEMBL2387470 | — | — | 1 | 8.11 |
| CHEMBL2387476 | — | — | 1 | 7.75 |
| CHEMBL2387477 | — | — | 1 | 7.68 |
| CHEMBL2387467 | — | — | 1 | 7.51 |
| CHEMBL2387466 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2387464 | — | Ki | = | 0.032 | nM | 10.49 |
| CHEMBL2387465 | — | Ki | = | 0.037 | nM | 10.43 |
| CHEMBL2387471 | — | Ki | = | 0.076 | nM | 10.12 |
| CHEMBL2387463 | — | Ki | = | 0.094 | nM | 10.03 |
| CHEMBL2387474 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL2387473 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL2387475 | — | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL2387472 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL2387479 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL2387469 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL2387468 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL2387462 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL2387478 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL2387470 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL2387476 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL2387477 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL2387467 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL2387466 | — | Ki | = | 250.0 | nM | 6.60 |