Assay Detail
Binding
CHEMBL2388468
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inverse agonist activity at human cytomegalovirus US28 receptor transfected in HEK293T cells assessed as activation of MAPK signaling pathway after 20 to 24 hrs by luciferase-based Elk1 reporter gene assay
40
Total Activities
21
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human betaherpesvirus 5 |
| Cell Type | HEK-293T |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Development of flavonoid-based inverse agonists of the key signaling receptor US28 of human cytomegalovirus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 39 | 5.45 | 6.51 |
| pEC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2386689 | — | — | 2 | 6.51 |
| CHEMBL2386683 | — | — | 2 | 6.10 |
| CHEMBL2386688 | — | — | 2 | 5.88 |
| CHEMBL594854 | — | — | 2 | 5.85 |
| CHEMBL2386690 | — | — | 2 | 5.75 |
| CHEMBL2386681 | — | — | 2 | 5.54 |
| CHEMBL2386541 | — | — | 2 | 5.46 |
| CHEMBL244746 | — | — | 2 | 5.34 |
| CHEMBL2386673 | — | — | 2 | 5.31 |
| CHEMBL2386671 | — | — | 2 | 5.30 |
| CHEMBL2386675 | — | — | 2 | 5.26 |
| CHEMBL2386674 | — | — | 2 | 5.22 |
| CHEMBL2386677 | — | — | 2 | 5.19 |
| CHEMBL2386672 | — | — | 2 | 5.18 |
| CHEMBL2386540 | — | — | 2 | 5.14 |
| CHEMBL2386670 | — | — | 2 | 5.11 |
| CHEMBL2386676 | — | — | 2 | 5.11 |
| CHEMBL2386542 | — | — | 2 | 5.09 |
| CHEMBL2386678 | — | — | 2 | 5.00 |
| CHEMBL2386679 | — | — | 1 | - |
| CHEMBL2386680 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2386689 | — | EC50 | = | 309.03 | nM | 6.51 |
| CHEMBL2386689 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL2386683 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2386683 | — | EC50 | = | 831.76 | nM | 6.08 |
| CHEMBL2386688 | — | EC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL2386688 | — | EC50 | = | 1318.26 | nM | 5.88 |
| CHEMBL594854 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL594854 | — | EC50 | = | 1445.44 | nM | 5.84 |
| CHEMBL2386690 | — | EC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL2386690 | — | EC50 | = | 1778.28 | nM | 5.75 |
| CHEMBL2386681 | — | EC50 | = | 2884.03 | nM | 5.54 |
| CHEMBL2386681 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2386541 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL2386541 | — | EC50 | = | 3467.37 | nM | 5.46 |
| CHEMBL244746 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL244746 | — | EC50 | = | 4570.88 | nM | 5.34 |
| CHEMBL2386673 | — | EC50 | = | 4897.79 | nM | 5.31 |
| CHEMBL2386673 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL2386671 | — | EC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL2386671 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2386675 | — | EC50 | = | 5495.41 | nM | 5.26 |
| CHEMBL2386675 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL2386674 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL2386674 | — | EC50 | = | 6025.6 | nM | 5.22 |
| CHEMBL2386677 | — | EC50 | = | 6456.54 | nM | 5.19 |
| CHEMBL2386677 | — | EC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL2386672 | — | EC50 | = | 6606.93 | nM | 5.18 |
| CHEMBL2386672 | — | EC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL2386540 | — | EC50 | = | 7244.36 | nM | 5.14 |
| CHEMBL2386540 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL2386676 | — | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL2386676 | — | EC50 | = | 7762.47 | nM | 5.11 |
| CHEMBL2386670 | — | EC50 | = | 7762.47 | nM | 5.11 |
| CHEMBL2386670 | — | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL2386542 | — | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL2386542 | — | EC50 | = | 8128.31 | nM | 5.09 |
| CHEMBL2386678 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2386680 | — | EC50 | - | — | - | |
| CHEMBL2386678 | — | pEC50 | - | — | - | |
| CHEMBL2386679 | — | EC50 | - | — | - |