Assay Detail
Functional
CHEMBL2388596
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Human simplex virus 1 KOS infected in human HEL cells assessed as reduction of virus-induced cytopathicity measured at day 3 by microscopic analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Ester prodrugs of acyclic nucleoside thiophosphonates compared to phosphonates: synthesis, antiviral activity and decomposition study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.10 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 7.10 |
| CHEMBL922 | ADEFOVIR DIPIVOXIL | 4.0 | 1 | 6.70 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 6.05 |
| CHEMBL2386205 | — | — | 1 | 5.41 |
| CHEMBL1538 | TENOFOVIR DISOPROXIL | 4.0 | 1 | 5.24 |
| CHEMBL2386206 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184 | ACYCLOVIR | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL922 | ADEFOVIR DIPIVOXIL | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2386205 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1538 | TENOFOVIR DISOPROXIL | EC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL2386206 | — | EC50 | > | 50000.0 | nM | - |