Assay Detail
Functional
CHEMBL2388598
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV-1 3B infected in human CEM cells assessed as inhibition of syncytia formation after 4 days by microscopic analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Ester prodrugs of acyclic nucleoside thiophosphonates compared to phosphonates: synthesis, antiviral activity and decomposition study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.40 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1538 | TENOFOVIR DISOPROXIL | 4.0 | 1 | 7.80 |
| CHEMBL922 | ADEFOVIR DIPIVOXIL | 4.0 | 1 | 7.35 |
| CHEMBL2386206 | — | — | 1 | 7.04 |
| CHEMBL2386205 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1538 | TENOFOVIR DISOPROXIL | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL922 | ADEFOVIR DIPIVOXIL | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2386206 | — | EC50 | = | 92.0 | nM | 7.04 |
| CHEMBL2386205 | — | EC50 | >= | 200.0 | nM | - |