Assay Detail
Functional
CHEMBL2388780
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Phototoxicity against human A549 cells incubated for 24 hrs followed by exposure to visible-light for 10 mins measured after 24 hrs by WST assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cationic porphyrin-quinoxaline conjugate as a photochemically triggered novel cytotoxic agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.83 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2385808 | — | — | 1 | 7.22 |
| CHEMBL2385807 | — | — | 1 | 6.75 |
| CHEMBL65606 | TMPYP4 | — | 1 | 6.52 |
| CHEMBL2385809 | — | — | 1 | - |
| CHEMBL345046 | TETRAPHENYLPORPHYRIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2385808 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2385807 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL65606 | TMPYP4 | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2385809 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL345046 | TETRAPHENYLPORPHYRIN | IC50 | > | 20000.0 | nM | - |