Assay Detail
Binding
CHEMBL2388875
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Antagonists for the orphan G-protein-coupled receptor GPR55 based on a coumarin scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 4.99 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL559612 | CP-55940 | — | 1 | 5.22 |
| CHEMBL2177264 | — | — | 1 | 5.09 |
| CHEMBL111 | RIMONABANT | 4.0 | 1 | 5.00 |
| CHEMBL2387530 | — | — | 1 | 5.00 |
| CHEMBL2387744 | — | — | 1 | 4.95 |
| CHEMBL2181542 | — | — | 1 | 4.90 |
| CHEMBL2181540 | — | — | 1 | 4.80 |
| CHEMBL2387538 | — | — | 1 | - |
| CHEMBL2177263 | — | — | 1 | - |
| CHEMBL2387539 | — | — | 1 | - |
| CHEMBL2177257 | — | — | 1 | - |
| CHEMBL2181546 | — | — | 1 | - |
| CHEMBL2177250 | — | — | 1 | - |
| CHEMBL2177253 | — | — | 1 | - |
| CHEMBL2177254 | — | — | 1 | - |
| CHEMBL2177259 | — | — | 1 | - |
| CHEMBL2177260 | — | — | 1 | - |
| CHEMBL2387532 | — | — | 1 | - |
| CHEMBL2387537 | — | — | 1 | - |
| CHEMBL2387536 | — | — | 1 | - |
| CHEMBL2387535 | — | — | 1 | - |
| CHEMBL2387534 | — | — | 1 | - |
| CHEMBL2387533 | — | — | 1 | - |
| CHEMBL470199 | — | — | 1 | - |
| CHEMBL2181551 | — | — | 1 | - |
| CHEMBL506746 | — | — | 1 | - |
| CHEMBL2177249 | — | — | 1 | - |
| CHEMBL2387743 | — | — | 1 | - |
| CHEMBL2181549 | — | — | 1 | - |
| CHEMBL470224 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL559612 | CP-55940 | IC50 | = | 5990.0 | nM | 5.22 |
| CHEMBL2177264 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL111 | RIMONABANT | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL2387530 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2387744 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL2181542 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL2181540 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL2177257 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2181545 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2181546 | — | IC50 | >= | 10000.0 | nM | - |
| CHEMBL2177250 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2177253 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2177254 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2177259 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2177260 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2387532 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2177263 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2181539 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2181541 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2181543 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2181544 | — | IC50 | >= | 10000.0 | nM | - |
| CHEMBL2387539 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2387538 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2387537 | — | IC50 | >= | 10000.0 | nM | - |
| CHEMBL2387536 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2387535 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2387534 | — | IC50 | >= | 10000.0 | nM | - |
| CHEMBL2387533 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL470199 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2181551 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL506746 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2177249 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2387743 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2181549 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL470224 | — | IC50 | > | 10000.0 | nM | - |