Assay Detail
Functional
CHEMBL2389361
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human RKO cells expressing wild type p53 assessed as cell viability after 5 days by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RKO |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.00 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2386348 | — | — | 1 | 6.52 |
| CHEMBL2386347 | — | — | 1 | 6.52 |
| CHEMBL2386345 | — | — | 1 | 6.52 |
| CHEMBL2386346 | RO-5045337 | 1.0 | 1 | 6.40 |
| CHEMBL2386344 | — | — | 1 | 6.40 |
| CHEMBL2386349 | — | — | 1 | 6.30 |
| CHEMBL2386343 | — | — | 1 | 6.30 |
| CHEMBL2386169 | — | — | 1 | 6.30 |
| CHEMBL2386350 | — | — | 1 | 6.22 |
| CHEMBL191334 | NUTLIN-3 | — | 1 | 5.82 |
| CHEMBL2386170 | — | — | 1 | 5.17 |
| CHEMBL2386351 | — | — | 1 | 4.90 |
| CHEMBL2386168 | — | — | 1 | 4.62 |
| CHEMBL2386167 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2386348 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2386347 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2386345 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2386346 | RO-5045337 | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2386344 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2386349 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2386343 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2386169 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2386350 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2386170 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL2386351 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL2386168 | — | IC50 | = | 23700.0 | nM | 4.62 |
| CHEMBL2386167 | — | IC50 | > | 30000.0 | nM | - |