Assay Detail
Functional
CHEMBL2389880
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human FFA1 receptor transfected in human 1321N1 cells by calcium mobilization assay
23
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1321-N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 6.97 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2386353 | — | — | 2 | 8.22 |
| CHEMBL2386363 | — | — | 1 | 7.77 |
| CHEMBL2386355 | — | — | 1 | 7.74 |
| CHEMBL2386364 | — | — | 1 | 7.74 |
| CHEMBL2315528 | — | — | 1 | 7.70 |
| CHEMBL2386362 | — | — | 1 | 7.65 |
| CHEMBL2386361 | — | — | 1 | 7.48 |
| CHEMBL2386359 | — | — | 1 | 7.45 |
| CHEMBL2386365 | — | — | 1 | 7.42 |
| CHEMBL449588 | — | — | 1 | 7.34 |
| CHEMBL2386354 | — | — | 1 | 7.13 |
| CHEMBL2386360 | — | — | 1 | 6.85 |
| CHEMBL2386358 | — | — | 1 | 6.84 |
| CHEMBL488384 | — | — | 1 | 6.70 |
| CHEMBL2386369 | — | — | 1 | 6.44 |
| CHEMBL2386371 | — | — | 1 | 6.43 |
| CHEMBL2386368 | — | — | 1 | 6.21 |
| CHEMBL2386370 | — | — | 1 | 6.14 |
| CHEMBL2386366 | — | — | 1 | 5.84 |
| CHEMBL2386367 | — | — | 1 | 5.71 |
| CHEMBL2386356 | — | — | 1 | 5.67 |
| CHEMBL2386357 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2386353 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2386353 | — | EC50 | = | 6.166 | nM | 8.21 |
| CHEMBL2386363 | — | EC50 | = | 16.98 | nM | 7.77 |
| CHEMBL2386355 | — | EC50 | = | 18.2 | nM | 7.74 |
| CHEMBL2386364 | — | EC50 | = | 18.2 | nM | 7.74 |
| CHEMBL2315528 | — | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL2386362 | — | EC50 | = | 22.39 | nM | 7.65 |
| CHEMBL2386361 | — | EC50 | = | 33.11 | nM | 7.48 |
| CHEMBL2386359 | — | EC50 | = | 35.48 | nM | 7.45 |
| CHEMBL2386365 | — | EC50 | = | 38.02 | nM | 7.42 |
| CHEMBL449588 | — | EC50 | = | 45.71 | nM | 7.34 |
| CHEMBL2386354 | — | EC50 | = | 74.13 | nM | 7.13 |
| CHEMBL2386360 | — | EC50 | = | 141.25 | nM | 6.85 |
| CHEMBL2386358 | — | EC50 | = | 144.54 | nM | 6.84 |
| CHEMBL488384 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL2386369 | — | EC50 | = | 363.08 | nM | 6.44 |
| CHEMBL2386371 | — | EC50 | = | 371.54 | nM | 6.43 |
| CHEMBL2386368 | — | EC50 | = | 616.6 | nM | 6.21 |
| CHEMBL2386370 | — | EC50 | = | 724.44 | nM | 6.14 |
| CHEMBL2386366 | — | EC50 | = | 1445.44 | nM | 5.84 |
| CHEMBL2386367 | — | EC50 | = | 1949.84 | nM | 5.71 |
| CHEMBL2386356 | — | EC50 | = | 2137.96 | nM | 5.67 |
| CHEMBL2386357 | — | EC50 | = | 2511.89 | nM | 5.60 |