Assay Detail
Binding
CHEMBL2389974
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Inhibition of recombinant GST-tagged p38alpha MAP kinase (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tri-substituted imidazole analogues of SB203580 as inducers for cardiomyogenesis of human embryonic stem cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.65 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2385554 | — | — | 1 | 8.37 |
| CHEMBL2385555 | — | — | 1 | 8.33 |
| CHEMBL2385556 | — | — | 1 | 8.08 |
| CHEMBL2385557 | — | — | 1 | 7.70 |
| CHEMBL2385551 | — | — | 1 | 7.62 |
| CHEMBL10 | SB-203580 | — | 1 | 7.60 |
| CHEMBL2385553 | — | — | 1 | 7.14 |
| CHEMBL2385552 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2385554 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL2385555 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL2385556 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL2385557 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2385551 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL10 | SB-203580 | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2385553 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL2385552 | — | IC50 | = | 454.0 | nM | 6.34 |