Assay Detail
Binding
CHEMBL2390089
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Inhibition of human NEU3 using 4-MU-NANA as substrate preincubated for 15 mins before substrate addition measured after 30 mins by fluorescence plate reader analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of Selective Nanomolar Inhibitors of the Human Neuraminidase, NEU4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.76 | 5.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1289428 | — | — | 1 | 5.34 |
| CHEMBL1289862 | — | — | 1 | 5.33 |
| CHEMBL1289649 | — | — | 1 | 5.26 |
| CHEMBL96712 | NEU5AC2EN | — | 1 | 5.20 |
| CHEMBL1289311 | — | — | 1 | 4.71 |
| CHEMBL1289754 | — | — | 1 | 4.42 |
| CHEMBL1289755 | — | — | 1 | 4.41 |
| CHEMBL1289650 | — | — | 1 | 4.10 |
| CHEMBL1289540 | — | — | 1 | 4.05 |
| CHEMBL1289979 | — | — | 1 | - |
| CHEMBL1289861 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1289428 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL1289862 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1289649 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL96712 | NEU5AC2EN | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL1289311 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL1289754 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL1289755 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL1289650 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL1289540 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL1289979 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL1289861 | — | IC50 | = | 180000.0 | nM | - |