Assay Detail
Binding
CHEMBL2390113
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NorA in Staphylococcus aureus 1199B harboring grlA A116E mutant assessed as inhibition of ethidium bromide efflux measured for 5 mins by fluorometric analysis
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Quinolone resistance protein NorA (CHEMBL5114) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus |
Publication
Re-evolution of the 2-phenylquinolines: ligand-based design, synthesis, and biological evaluation of a potent new class of Staphylococcus aureus NorA efflux pump inhibitors to combat antimicrobial resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.08 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2385690 | — | — | 1 | 5.42 |
| CHEMBL2385681 | — | — | 1 | 5.41 |
| CHEMBL2385684 | — | — | 1 | 5.19 |
| CHEMBL2385677 | — | — | 1 | 5.12 |
| CHEMBL2385678 | — | — | 1 | 5.10 |
| CHEMBL2385688 | — | — | 1 | 5.08 |
| CHEMBL2385680 | — | — | 1 | 5.08 |
| CHEMBL2385667 | — | — | 1 | 5.07 |
| CHEMBL1651180 | — | — | 1 | 5.05 |
| CHEMBL772 | RESERPINE | 4.0 | 1 | 5.04 |
| CHEMBL2385691 | — | — | 1 | 5.04 |
| CHEMBL2385683 | — | — | 1 | 5.03 |
| CHEMBL2385675 | — | — | 1 | 5.03 |
| CHEMBL2385689 | — | — | 1 | 5.01 |
| CHEMBL2385670 | — | — | 1 | 5.00 |
| CHEMBL2385682 | — | — | 1 | 4.97 |
| CHEMBL2385676 | — | — | 1 | 4.88 |
| CHEMBL2385679 | — | — | 1 | 4.83 |
| CHEMBL2385668 | — | — | 1 | - |
| CHEMBL2385692 | — | — | 1 | - |
| CHEMBL2385687 | — | — | 1 | - |
| CHEMBL2385686 | — | — | 1 | - |
| CHEMBL2385685 | — | — | 1 | - |
| CHEMBL2385674 | — | — | 1 | - |
| CHEMBL2385673 | — | — | 1 | - |
| CHEMBL2385672 | — | — | 1 | - |
| CHEMBL2385671 | — | — | 1 | - |
| CHEMBL2385669 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2385690 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL2385681 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL2385684 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL2385677 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL2385678 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2385688 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL2385680 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL2385667 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL1651180 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL772 | RESERPINE | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL2385691 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL2385683 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL2385675 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL2385689 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL2385670 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL2385682 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL2385676 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL2385679 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL2385668 | — | IC50 | - | — | - | |
| CHEMBL2385692 | — | IC50 | - | — | - | |
| CHEMBL2385687 | — | IC50 | - | — | - | |
| CHEMBL2385686 | — | IC50 | - | — | - | |
| CHEMBL2385685 | — | IC50 | - | — | - | |
| CHEMBL2385674 | — | IC50 | - | — | - | |
| CHEMBL2385673 | — | IC50 | - | — | - | |
| CHEMBL2385672 | — | IC50 | - | — | - | |
| CHEMBL2385671 | — | IC50 | - | — | - | |
| CHEMBL2385669 | — | IC50 | - | — | - |