Assay Detail
Functional
CHEMBL2390131
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Antiinflammatory activity in Balb/c mouse splenocytes assessed as LPS-induced TNF-alpha production after 18 to 24 hrs by AlphaLISA
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Splenocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.68 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2385759 | — | — | 1 | 9.10 |
| CHEMBL193240 | ROFLUMILAST | 4.0 | 1 | 8.92 |
| CHEMBL2385757 | — | — | 1 | 8.33 |
| CHEMBL2385758 | — | — | 1 | 8.07 |
| CHEMBL2385753 | — | — | 1 | 8.07 |
| CHEMBL2385755 | — | — | 1 | 8.01 |
| CHEMBL2385756 | — | — | 1 | 7.89 |
| CHEMBL2385761 | — | — | 1 | 7.77 |
| CHEMBL2385760 | — | — | 1 | 7.75 |
| CHEMBL2385754 | — | — | 1 | 7.46 |
| CHEMBL2385573 | — | — | 1 | 7.05 |
| CHEMBL2385559 | — | — | 1 | 6.66 |
| CHEMBL2385749 | — | — | 1 | 6.41 |
| CHEMBL2385563 | — | — | 1 | 6.01 |
| CHEMBL2385751 | — | — | 1 | - |
| CHEMBL2385750 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2385759 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL193240 | ROFLUMILAST | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL2385757 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL2385758 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL2385753 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL2385755 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL2385756 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2385761 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2385760 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2385754 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2385573 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2385559 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2385749 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL2385563 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL2385751 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2385750 | — | IC50 | > | 10000.0 | nM | - |