Assay Detail
Binding
CHEMBL2390229
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]mesulergine from 5HT2C receptor in rat cerebral cortex after 15 mins by liquid scintillation counting analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological investigation of coumarin piperazine (piperidine) derivatives as potential multireceptor atypical antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.94 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2387260 | — | — | 1 | 7.92 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 7.84 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.79 |
| CHEMBL2387230 | — | — | 1 | 7.16 |
| CHEMBL2387265 | — | — | 1 | 6.59 |
| CHEMBL2385102 | — | — | 1 | 6.41 |
| CHEMBL2387253 | — | — | 1 | 6.00 |
| CHEMBL2387229 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2387260 | — | Ki | = | 11.9 | nM | 7.92 |
| CHEMBL85 | RISPERIDONE | Ki | = | 14.5 | nM | 7.84 |
| CHEMBL42 | CLOZAPINE | Ki | = | 16.2 | nM | 7.79 |
| CHEMBL2387230 | — | Ki | = | 68.9 | nM | 7.16 |
| CHEMBL2387265 | — | Ki | = | 256.2 | nM | 6.59 |
| CHEMBL2385102 | — | Ki | = | 389.3 | nM | 6.41 |
| CHEMBL2387253 | — | Ki | = | 999.5 | nM | 6.00 |
| CHEMBL2387229 | — | Ki | = | 1700.7 | nM | 5.77 |