Assay Detail
Binding
CHEMBL2390231
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]rauwolscine from alpha-2 adrenergic receptor in rat cerebral cortex after 60 mins by liquid scintillation counting analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and biological investigation of coumarin piperazine (piperidine) derivatives as potential multireceptor atypical antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.11 | 7.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2387229 | — | — | 1 | 7.81 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 7.53 |
| CHEMBL2387265 | — | — | 1 | 7.33 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.25 |
| CHEMBL2387253 | — | — | 1 | 7.06 |
| CHEMBL2385102 | — | — | 1 | 6.91 |
| CHEMBL2387260 | — | — | 1 | 6.80 |
| CHEMBL2387230 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2387229 | — | Ki | = | 15.6 | nM | 7.81 |
| CHEMBL85 | RISPERIDONE | Ki | = | 29.5 | nM | 7.53 |
| CHEMBL2387265 | — | Ki | = | 46.9 | nM | 7.33 |
| CHEMBL42 | CLOZAPINE | Ki | = | 55.6 | nM | 7.25 |
| CHEMBL2387253 | — | Ki | = | 86.9 | nM | 7.06 |
| CHEMBL2385102 | — | Ki | = | 124.3 | nM | 6.91 |
| CHEMBL2387260 | — | Ki | = | 159.6 | nM | 6.80 |
| CHEMBL2387230 | — | Ki | = | 598.6 | nM | 6.22 |