Assay Detail
Binding
CHEMBL2390364
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TYK2 in human NK92 cells assessed as inhibition of IL12-induced STAT4 phosphorylation incubated for 20 mins followed by IL12 challenge for 45 mins
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NK92 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.10 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2386635 | — | — | 1 | 7.00 |
| CHEMBL2386629 | — | — | 1 | 6.51 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 6.15 |
| CHEMBL2386636 | — | — | 1 | 6.01 |
| CHEMBL2385096 | — | — | 1 | 5.66 |
| CHEMBL2386633 | — | — | 1 | 5.25 |
| CHEMBL2386653 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2386635 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2386629 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL221959 | TOFACITINIB | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL2386636 | — | EC50 | = | 980.0 | nM | 6.01 |
| CHEMBL2385096 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2386633 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL2386653 | — | EC50 | > | 5800.0 | nM | - |