Assay Detail
Binding
CHEMBL2390527
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BMP4 in mouse C2C12BRA cells after 14 hrs by luciferase reporter gene assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.41 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2385596 | — | — | 1 | 7.60 |
| CHEMBL2385600 | — | — | 1 | 7.03 |
| CHEMBL2385591 | — | — | 1 | 6.93 |
| CHEMBL2385579 | — | — | 1 | 6.85 |
| CHEMBL502351 | — | — | 1 | 6.82 |
| CHEMBL2385588 | — | — | 1 | 6.61 |
| CHEMBL2385585 | — | — | 1 | 6.38 |
| CHEMBL2385595 | — | — | 1 | 6.28 |
| CHEMBL2385581 | — | — | 1 | 6.28 |
| CHEMBL2385592 | — | — | 1 | 5.58 |
| CHEMBL2385578 | — | — | 1 | 5.34 |
| CHEMBL2385403 | — | — | 1 | 5.17 |
| CHEMBL2385589 | — | — | 1 | - |
| CHEMBL2385587 | — | — | 1 | - |
| CHEMBL2385584 | — | — | 1 | - |
| CHEMBL2385583 | — | — | 1 | - |
| CHEMBL2385580 | — | — | 1 | - |
| CHEMBL2385577 | — | — | 1 | - |
| CHEMBL2385576 | — | — | 1 | - |
| CHEMBL2385575 | — | — | 1 | - |
| CHEMBL2385574 | — | — | 1 | - |
| CHEMBL454786 | — | — | 1 | - |
| CHEMBL2385601 | — | — | 1 | - |
| CHEMBL2385599 | — | — | 1 | - |
| CHEMBL467142 | — | — | 1 | - |
| CHEMBL2385594 | — | — | 1 | - |
| CHEMBL2385586 | — | — | 1 | - |
| CHEMBL2385582 | — | — | 1 | - |
| CHEMBL511563 | — | — | 1 | - |
| CHEMBL2385598 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2385596 | — | IC50 | = | 25.2 | nM | 7.60 |
| CHEMBL2385600 | — | IC50 | = | 94.1 | nM | 7.03 |
| CHEMBL2385591 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL2385579 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL502351 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL2385588 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL2385585 | — | IC50 | = | 418.0 | nM | 6.38 |
| CHEMBL2385595 | — | IC50 | = | 523.0 | nM | 6.28 |
| CHEMBL2385581 | — | IC50 | = | 529.0 | nM | 6.28 |
| CHEMBL2385592 | — | IC50 | = | 2636.0 | nM | 5.58 |
| CHEMBL2385578 | — | IC50 | = | 4571.0 | nM | 5.34 |
| CHEMBL2385403 | — | IC50 | = | 6732.0 | nM | 5.17 |
| CHEMBL2385593 | — | IC50 | - | — | - | |
| CHEMBL2385590 | — | IC50 | - | — | - | |
| CHEMBL2385589 | — | IC50 | - | — | - | |
| CHEMBL2385587 | — | IC50 | - | — | - | |
| CHEMBL2385584 | — | IC50 | - | — | - | |
| CHEMBL2385583 | — | IC50 | - | — | - | |
| CHEMBL2385580 | — | IC50 | - | — | - | |
| CHEMBL2385577 | — | IC50 | - | — | - | |
| CHEMBL2385576 | — | IC50 | - | — | - | |
| CHEMBL2385575 | — | IC50 | - | — | - | |
| CHEMBL2385574 | — | IC50 | - | — | - | |
| CHEMBL454786 | — | IC50 | - | — | - | |
| CHEMBL2385601 | — | IC50 | - | — | - | |
| CHEMBL2385599 | — | IC50 | - | — | - | |
| CHEMBL467142 | — | IC50 | - | — | - | |
| CHEMBL2385594 | — | IC50 | - | — | - | |
| CHEMBL2385586 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL2385582 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL511563 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL2385598 | — | IC50 | - | — | - |