Assay Detail
Functional
CHEMBL2390584
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Neuroprotective activity in rat primary cortical neurons assessed as decrease in FeSO4-induced oxidative stress measured cell viability after 24 hrs by MTT assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Cerebral cortex neuron |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Highly efficient biocompatible neuroprotectants with dual activity as antioxidants and P2Y receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.59 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3392138 | — | — | 1 | 6.77 |
| CHEMBL2386492 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3392138 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2386492 | — | EC50 | = | 400.0 | nM | 6.40 |