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Assay Detail

CHEMBL2390599

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type 1321-N1
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

P2Y purinoceptor 11 (CHEMBL4867)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Highly efficient biocompatible neuroprotectants with dual activity as antioxidants and P2Y receptor agonists.
Azran S, Förster D, Danino O, Nadel Y, Reiser G, Fischer B.
J Med Chem (2013) 56 : 4938 -4952
PubMed 23751098 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 16 5.81 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2386496 1 6.89
CHEMBL2386492 1 6.00
CHEMBL2386495 1 5.85
CHEMBL2386490 1 5.82
CHEMBL14830 ADENOSINE DIPHOSPHATE 0.5 1 5.77
CHEMBL2181938 1 5.54
CHEMBL3392138 1 5.43
CHEMBL14249 ADENOSINE TRIPHOSPHATE 2.0 1 5.17
CHEMBL2386499 1 -
CHEMBL2386498 1 -
CHEMBL2386497 1 -
CHEMBL2386494 1 -
CHEMBL2386493 1 -
CHEMBL2181939 1 -
CHEMBL437508 1 -
CHEMBL435402 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2386496 EC50 = 130.0 nM 6.89
CHEMBL2386492 EC50 = 1000.0 nM 6.00
CHEMBL2386495 EC50 = 1400.0 nM 5.85
CHEMBL2386490 EC50 = 1500.0 nM 5.82
CHEMBL14830 ADENOSINE DIPHOSPHATE EC50 = 1700.0 nM 5.77
CHEMBL2181938 EC50 = 2900.0 nM 5.54
CHEMBL3392138 EC50 = 3680.0 nM 5.43
CHEMBL14249 ADENOSINE TRIPHOSPHATE EC50 = 6700.0 nM 5.17
CHEMBL2386499 EC50 - -
CHEMBL2386498 EC50 - -
CHEMBL2386497 EC50 - -
CHEMBL2386494 EC50 - -
CHEMBL2386493 EC50 - -
CHEMBL2181939 EC50 - -
CHEMBL437508 EC50 - -
CHEMBL435402 EC50 - -