Assay Detail
Functional
CHEMBL2390652
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 trypomastigotes after 72 hrs by Alamar blue assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.29 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.12 |
| CHEMBL1946928 | — | — | 1 | 4.74 |
| CHEMBL1946927 | — | — | 1 | 4.72 |
| CHEMBL1946929 | — | — | 1 | 4.47 |
| CHEMBL1946738 | — | — | 1 | 4.38 |
| CHEMBL2386133 | — | — | 1 | - |
| CHEMBL2386132 | — | — | 1 | - |
| CHEMBL2386131 | — | — | 1 | - |
| CHEMBL1946741 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL1946928 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL1946927 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL1946929 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL1946738 | — | IC50 | = | 42100.0 | nM | 4.38 |
| CHEMBL2386133 | — | IC50 | = | 230300.0 | nM | - |
| CHEMBL2386132 | — | IC50 | = | 117400.0 | nM | - |
| CHEMBL2386131 | — | IC50 | = | 138900.0 | nM | - |
| CHEMBL1946741 | — | IC50 | = | 293800.0 | nM | - |