Assay Detail
Binding
CHEMBL2390679
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of amyloid beta (1 to 42) aggregation (unknown origin) at 4:1 compound to protein concentration after 48 hrs by thioflavin T fluorescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Progress and developments in tau aggregation inhibitors for Alzheimer disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.00 | 4.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2386874 | — | — | 1 | 4.00 |
| CHEMBL2386881 | CAPROSPINOL | — | 1 | 4.00 |
| CHEMBL497 | CLIOQUINOL | 4.0 | 1 | 4.00 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 4.00 |
| CHEMBL468154 | SCYLLITOL | 2.0 | 1 | 4.00 |
| CHEMBL149082 | TRAMIPROSATE | 3.0 | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2386874 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2386881 | CAPROSPINOL | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL497 | CLIOQUINOL | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL468154 | SCYLLITOL | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL149082 | TRAMIPROSATE | IC50 | = | 100000.0 | nM | 4.00 |