Assay Detail
ADMET
CHEMBL2393746
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against rat L6 cells assessed as growth inhibition after 70 hrs by Alamar blue staining-based inverted microscopic analysis
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antimalarial testing of neocryptolepine analogues: addition of ester function in SAR study of 2,11-disubstituted indolo[2,3-b]quinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.93 | 7.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.84 |
| CHEMBL2391249 | — | — | 1 | 6.66 |
| CHEMBL2391252 | — | — | 1 | 6.57 |
| CHEMBL2058009 | — | — | 1 | 6.55 |
| CHEMBL2391251 | — | — | 1 | 6.50 |
| CHEMBL2391246 | — | — | 1 | 6.47 |
| CHEMBL2391090 | — | — | 1 | 6.40 |
| CHEMBL2391087 | — | — | 1 | 6.39 |
| CHEMBL2391248 | — | — | 1 | 6.37 |
| CHEMBL2391250 | — | — | 1 | 6.36 |
| CHEMBL2391095 | — | — | 1 | 6.24 |
| CHEMBL2391241 | — | — | 1 | 6.20 |
| CHEMBL2391253 | — | — | 1 | 6.19 |
| CHEMBL2391094 | — | — | 1 | 6.12 |
| CHEMBL2391088 | — | — | 1 | 6.09 |
| CHEMBL2391089 | — | — | 1 | 5.98 |
| CHEMBL2391086 | — | — | 1 | 5.95 |
| CHEMBL2391247 | — | — | 1 | 5.86 |
| CHEMBL2391096 | — | — | 1 | 5.59 |
| CHEMBL2391097 | — | — | 1 | 5.55 |
| CHEMBL115585 | NEOCRYPTOLEPINE | — | 1 | 5.50 |
| CHEMBL2391242 | — | — | 1 | 5.48 |
| CHEMBL2391245 | — | — | 1 | 5.42 |
| CHEMBL2391244 | — | — | 1 | 5.21 |
| CHEMBL2391243 | — | — | 1 | 5.17 |
| CHEMBL2391092 | — | — | 1 | 4.70 |
| CHEMBL2391240 | — | — | 1 | 4.58 |
| CHEMBL2391093 | — | — | 1 | 4.18 |
| CHEMBL2391091 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL2391249 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL2391252 | — | IC50 | = | 268.0 | nM | 6.57 |
| CHEMBL2058009 | — | IC50 | = | 279.0 | nM | 6.55 |
| CHEMBL2391251 | — | IC50 | = | 315.0 | nM | 6.50 |
| CHEMBL2391246 | — | IC50 | = | 337.0 | nM | 6.47 |
| CHEMBL2391090 | — | IC50 | = | 401.0 | nM | 6.40 |
| CHEMBL2391087 | — | IC50 | = | 408.0 | nM | 6.39 |
| CHEMBL2391248 | — | IC50 | = | 427.0 | nM | 6.37 |
| CHEMBL2391250 | — | IC50 | = | 436.0 | nM | 6.36 |
| CHEMBL2391095 | — | IC50 | = | 581.0 | nM | 6.24 |
| CHEMBL2391241 | — | IC50 | = | 627.0 | nM | 6.20 |
| CHEMBL2391253 | — | IC50 | = | 639.0 | nM | 6.19 |
| CHEMBL2391094 | — | IC50 | = | 754.0 | nM | 6.12 |
| CHEMBL2391088 | — | IC50 | = | 819.0 | nM | 6.09 |
| CHEMBL2391089 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL2391086 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL2391247 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL2391096 | — | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL2391097 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL115585 | NEOCRYPTOLEPINE | IC50 | = | 3194.0 | nM | 5.50 |
| CHEMBL2391242 | — | IC50 | = | 3340.0 | nM | 5.48 |
| CHEMBL2391245 | — | IC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL2391244 | — | IC50 | = | 6190.0 | nM | 5.21 |
| CHEMBL2391243 | — | IC50 | = | 6740.0 | nM | 5.17 |
| CHEMBL2391092 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL2391240 | — | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL2391093 | — | IC50 | = | 66200.0 | nM | 4.18 |
| CHEMBL2391091 | — | IC50 | = | 113000.0 | nM | - |