Assay Detail
Binding
CHEMBL2394341
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Inhibition of DYRK1B (unknown origin)
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (CHEMBL5543) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.73 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2392364 | — | — | 1 | 8.15 |
| CHEMBL1877990 | — | — | 1 | 7.92 |
| CHEMBL2392365 | — | — | 1 | 7.75 |
| CHEMBL1868723 | — | — | 1 | 7.75 |
| CHEMBL1898197 | — | — | 1 | 7.42 |
| CHEMBL1885536 | — | — | 1 | 7.38 |
| CHEMBL1904905 | — | — | 1 | 7.26 |
| CHEMBL1902528 | — | — | 1 | 7.03 |
| CHEMBL1899256 | — | — | 1 | 6.95 |
| CHEMBL1892019 | — | — | 1 | 6.90 |
| CHEMBL2392368 | — | — | 1 | 6.86 |
| CHEMBL1884711 | — | — | 1 | 6.75 |
| CHEMBL2392360 | — | — | 1 | 6.39 |
| CHEMBL1898211 | — | — | 1 | 6.29 |
| CHEMBL2392367 | — | — | 1 | 6.22 |
| CHEMBL1872011 | — | — | 1 | 6.08 |
| CHEMBL2392359 | — | — | 1 | 6.06 |
| CHEMBL1899640 | — | — | 1 | 6.05 |
| CHEMBL1885748 | — | — | 1 | 5.94 |
| CHEMBL2392361 | — | — | 1 | 5.17 |
| CHEMBL1882945 | — | — | 1 | 5.05 |
| CHEMBL1331525 | — | — | 1 | - |
| CHEMBL2392362 | — | — | 1 | - |
| CHEMBL2392228 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2392364 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1877990 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2392365 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1868723 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1898197 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1885536 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1904905 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1902528 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL1899256 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL1892019 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL2392368 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL1884711 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL2392360 | — | IC50 | = | 411.0 | nM | 6.39 |
| CHEMBL1898211 | — | IC50 | = | 514.0 | nM | 6.29 |
| CHEMBL2392367 | — | IC50 | = | 599.0 | nM | 6.22 |
| CHEMBL1872011 | — | IC50 | = | 829.0 | nM | 6.08 |
| CHEMBL2392359 | — | IC50 | = | 871.0 | nM | 6.06 |
| CHEMBL1899640 | — | IC50 | = | 884.0 | nM | 6.05 |
| CHEMBL1885748 | — | IC50 | = | 1156.0 | nM | 5.94 |
| CHEMBL2392361 | — | IC50 | = | 6782.0 | nM | 5.17 |
| CHEMBL1882945 | — | IC50 | = | 8862.0 | nM | 5.05 |
| CHEMBL1331525 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2392362 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2392228 | — | IC50 | > | 10000.0 | nM | - |