Assay Detail
Binding
CHEMBL2394343
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Inhibition of CLK4 (unknown origin)
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein kinase CLK4 (CHEMBL4203) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.78 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2392364 | — | — | 1 | 8.40 |
| CHEMBL2392365 | — | — | 1 | 8.05 |
| CHEMBL1904905 | — | — | 1 | 7.89 |
| CHEMBL1898197 | — | — | 1 | 7.85 |
| CHEMBL1877990 | — | — | 1 | 7.80 |
| CHEMBL1899256 | — | — | 1 | 7.75 |
| CHEMBL1892019 | — | — | 1 | 7.52 |
| CHEMBL1868723 | — | — | 1 | 7.38 |
| CHEMBL1902528 | — | — | 1 | 7.22 |
| CHEMBL1885748 | — | — | 1 | 7.17 |
| CHEMBL1885536 | — | — | 1 | 7.12 |
| CHEMBL2392368 | — | — | 1 | 7.07 |
| CHEMBL2392360 | — | — | 1 | 7.04 |
| CHEMBL2392367 | — | — | 1 | 6.91 |
| CHEMBL1898211 | — | — | 1 | 6.62 |
| CHEMBL2392359 | — | — | 1 | 6.50 |
| CHEMBL2392228 | — | — | 1 | 6.28 |
| CHEMBL1884711 | — | — | 1 | 6.24 |
| CHEMBL1872011 | — | — | 1 | 5.89 |
| CHEMBL2392362 | — | — | 1 | 5.41 |
| CHEMBL1899640 | — | — | 1 | 5.26 |
| CHEMBL2392361 | — | — | 1 | 5.17 |
| CHEMBL1331525 | — | — | 1 | 5.12 |
| CHEMBL1882945 | — | — | 1 | 5.03 |
| CHEMBL2392366 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2392364 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2392365 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1904905 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1898197 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1877990 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1899256 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1892019 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1868723 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1902528 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1885748 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1885536 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL2392368 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL2392360 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL2392367 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL1898211 | — | IC50 | = | 241.0 | nM | 6.62 |
| CHEMBL2392359 | — | IC50 | = | 319.0 | nM | 6.50 |
| CHEMBL2392228 | — | IC50 | = | 526.0 | nM | 6.28 |
| CHEMBL1884711 | — | IC50 | = | 574.0 | nM | 6.24 |
| CHEMBL1872011 | — | IC50 | = | 1294.0 | nM | 5.89 |
| CHEMBL2392362 | — | IC50 | = | 3858.0 | nM | 5.41 |
| CHEMBL1899640 | — | IC50 | = | 5450.0 | nM | 5.26 |
| CHEMBL2392361 | — | IC50 | = | 6806.0 | nM | 5.17 |
| CHEMBL1331525 | — | IC50 | = | 7535.0 | nM | 5.12 |
| CHEMBL1882945 | — | IC50 | = | 9284.0 | nM | 5.03 |
| CHEMBL2392366 | — | IC50 | > | 10000.0 | nM | - |