Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2394347

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of CLK4 (unknown origin) by bioluminescence assay
ChEMBL ↗
96
Total Activities
96
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Dual specificity protein kinase CLK4 (CHEMBL4203) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315.
Coombs TC, Tanega C, Shen M, Wang JL, Auld DS, Gerritz SW, Schoenen FJ, Thomas CJ, Aubé J.
Bioorg Med Chem Lett (2013) 23 : 3654 -3661
PubMed 23642479 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 96 5.48 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1877990 — — 1 7.70
CHEMBL1892019 — — 1 7.52
CHEMBL1902528 — — 1 7.52
CHEMBL1898197 — — 1 7.40
CHEMBL2392365 — — 1 7.40
CHEMBL1894742 — — 1 7.40
CHEMBL2392363 — — 1 7.30
CHEMBL2392364 — — 1 7.30
CHEMBL1357018 — — 1 7.20
CHEMBL1868723 — — 1 7.16
CHEMBL1899256 — — 1 7.10
CHEMBL1904905 — — 1 6.92
CHEMBL1885536 — — 1 6.92
CHEMBL2392368 — — 1 6.89
CHEMBL1885748 — — 1 6.89
CHEMBL1884711 — — 1 6.82
CHEMBL2392360 — — 1 6.68
CHEMBL2392359 — — 1 6.54
CHEMBL1872011 — — 1 6.54
CHEMBL1898211 — — 1 6.54
CHEMBL1899640 — — 1 6.43
CHEMBL2392228 — — 1 6.24
CHEMBL1356808 — — 1 6.10
CHEMBL2392231 — — 1 5.79
CHEMBL1440157 — — 1 5.66
CHEMBL2392229 — — 1 5.63
CHEMBL2392362 — — 1 5.43
CHEMBL2392243 — — 1 5.39
CHEMBL2392230 — — 1 5.33
CHEMBL2392224 — — 1 5.28

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1877990 — IC50 = 20.0 nM 7.70
CHEMBL1892019 — IC50 = 30.0 nM 7.52
CHEMBL1902528 — IC50 = 30.0 nM 7.52
CHEMBL1898197 — IC50 = 40.0 nM 7.40
CHEMBL2392365 — IC50 = 40.0 nM 7.40
CHEMBL1894742 — IC50 = 40.0 nM 7.40
CHEMBL2392363 — IC50 = 50.0 nM 7.30
CHEMBL2392364 — IC50 = 50.0 nM 7.30
CHEMBL1357018 — IC50 = 63.0 nM 7.20
CHEMBL1868723 — IC50 = 70.0 nM 7.16
CHEMBL1899256 — IC50 = 80.0 nM 7.10
CHEMBL1904905 — IC50 = 120.0 nM 6.92
CHEMBL1885536 — IC50 = 120.0 nM 6.92
CHEMBL1885748 — IC50 = 130.0 nM 6.89
CHEMBL2392368 — IC50 = 130.0 nM 6.89
CHEMBL1884711 — IC50 = 150.0 nM 6.82
CHEMBL2392360 — IC50 = 210.0 nM 6.68
CHEMBL2392359 — IC50 = 290.0 nM 6.54
CHEMBL1872011 — IC50 = 290.0 nM 6.54
CHEMBL1898211 — IC50 = 290.0 nM 6.54
CHEMBL1899640 — IC50 = 370.0 nM 6.43
CHEMBL2392228 — IC50 = 580.0 nM 6.24
CHEMBL1356808 — IC50 = 790.0 nM 6.10
CHEMBL2392231 — IC50 = 1640.0 nM 5.79
CHEMBL1440157 — IC50 = 2200.0 nM 5.66
CHEMBL2392229 — IC50 = 2320.0 nM 5.63
CHEMBL2392362 — IC50 = 3680.0 nM 5.43
CHEMBL2392243 — IC50 = 4100.0 nM 5.39
CHEMBL2392230 — IC50 = 4630.0 nM 5.33
CHEMBL2392224 — IC50 = 5200.0 nM 5.28
CHEMBL2392225 — IC50 = 5200.0 nM 5.28
CHEMBL2392361 — IC50 = 5820.0 nM 5.24
CHEMBL2392367 — IC50 = 5820.0 nM 5.24
CHEMBL1882945 — IC50 = 5820.0 nM 5.24
CHEMBL1357429 — IC50 = 6540.0 nM 5.18
CHEMBL2392235 — IC50 = 8200.0 nM 5.09
CHEMBL2392227 — IC50 = 8200.0 nM 5.09
CHEMBL2392237 — IC50 = 8200.0 nM 5.09
CHEMBL1331525 — IC50 = 9230.0 nM 5.04
CHEMBL2392240 — IC50 = 9200.0 nM 5.04
CHEMBL2392244 — IC50 = 9200.0 nM 5.04
CHEMBL2392245 — IC50 = 9200.0 nM 5.04
CHEMBL2392391 — IC50 = 9200.0 nM 5.04
CHEMBL2392223 — IC50 = 10400.0 nM 4.98
CHEMBL2392222 — IC50 = 13000.0 nM 4.89
CHEMBL2392389 — IC50 = 13000.0 nM 4.89
CHEMBL2392226 — IC50 = 13000.0 nM 4.89
CHEMBL2392375 — IC50 = 13000.0 nM 4.89
CHEMBL2392385 — IC50 = 13000.0 nM 4.89
CHEMBL1318509 — IC50 = 14100.0 nM 4.85