Assay Detail
Binding
CHEMBL2394873
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Toxoplasma gondii enoyl acyl-carrier protein reductase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Enoyl-acyl carrier reductase (CHEMBL1250368) ↗| Type | SINGLE PROTEIN |
| Organism | Toxoplasma gondii |
Publication
Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.48 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL849 | TRICLOSAN | 4.0 | 1 | 7.82 |
| CHEMBL2392450 | — | — | 1 | 7.72 |
| CHEMBL2392447 | — | — | 1 | 7.54 |
| CHEMBL2392448 | — | — | 1 | 7.47 |
| CHEMBL2392449 | — | — | 1 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL849 | TRICLOSAN | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2392450 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2392447 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2392448 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL2392449 | — | IC50 | = | 137.0 | nM | 6.86 |